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Mihaylova et al

PFD's therapeutic effects on IPF involve the antioxidant mechanism of suppressing BACH1 and enhancing NRF2

3.2.6 O-GlcNAcylation O-GlcNAcylation is another type of PTM, which involves the addition of N-acetylglucosamine (GlcNAc) to Ser or Thr residues (Figure 4D)

Chang G-C

demonstrated that macrophages can absorb extracellular lactate to promote the lactylation of high mobility group box-1 (HMGB1), which is subsequently secreted via exosomes, increasing endothelial permeability and inducing further endothelial barrier dysfunction [163]